The Love in the Wild host, 39, will be featured on the July/August cover of Playboy, a rep for the magazine confirms to PEOPLE.
The mom of one, who also will strip down for a nude pictorial, first posed for Playboy in 1993. She later received the Playmate of the Year title.
The TV personality’s latest photo spread comes just before she turns the big 4-0 in November.
McCarthy has always worked hard on her fitness, but said in 2007 that she does sometimes splurge.
“I have my once-a-month nachos,” she explained, “but it’s [got] soy cheese and turkey chili on it, so it’s somewhat safe. But it’s still a big vice for me, because I have a big bowl of it.”